Sheep are large animals suitable for medical research due to their availability and acceptance by the animal research society. However, the model must be carefully chosen to ensure the analogy to humans, to avoid excessive use of animals and to prevent the waste of time, effort and resources. Different animal models can be used for pre-clinical studies. With the current focus on animal preservation in experimental studies, research proposals should consider the replacement of animals with validated alternative methods, and the animals' wellbeing should be the primary consideration in the provision of care at all stages of the experiment The animal models allow the development of basic knowledge that supports pre-clinical and clinical studies.Īmong the objectives for conducting research on animals are the collection of relevant information to understand the biology and wellbeing of humans and animals and the improvement and maintenance of health. In this context, it is necessary to conduct experimental studies to evaluate the effectiveness of these techniques, as well as the cytotoxicity and biological behavior of these materials.Įxperimental animal models have been widely used in biomedical research, because in vitro models are not able to fully mimic the human body's complexity.
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The technical and scientific advances made in recent decades have enabled the development and improvement of new health technologies, mainly regenerative techniques and biomaterials.